... it might be worth checking your PSUs maximum output of current through the 8pin and 6 pin connectors, AMD recommend 20A and 16A respectively....
This seems like a crazy amount of power, even for really overvolted cards. The stock power draw of the card is 300w, with 75w coming from the PCIE bus and 225w coming from the PCIE connectors. That is about 19A between the two connectors. It seems hard to believe the card could make use of nearly double that amount of power on the PCIE connectors; hopefully it is just an overestimate, but I suppose the closer you get to that recommendation the better your overvolting stability.