Those of you having crashing problems in Vista or otherwise might want to check out this thread and the threads it links to. I too was having crashing problems but I'm not able to play without crashes or desyncs in Vista x64 and it runs very well.
Thanks for the link - a lot of people claimed it helped, so I went ahead and bookmarked the fix and bought this on Amazon for $30 shipped (can't beat Prime, it'll be here tomorrow!).
I'll probably apply the fix before I start playing.
And I assume you meant now instead of not