DooKey
[H]F Junkie
- Joined
- Apr 25, 2001
- Messages
- 13,500
Yep, checked.
Follow along with the video below to see how to install our site as a web app on your home screen.
Note: This feature may not be available in some browsers.
We will be conducting a new beta test for a brand new application on WCG. This test will include features like intermediate uploads and trickle messages being sent to and from the host. For this first round of beta testing we will only be testing the application itself to make sure it works properly on all PC platforms. Intermediate uploads and trickle messaging from the client to the servers will be turned on and we will look at them. But will not do anything with the subsequent messages at this time.
This first Beta test will have over 3000 work units to be sent out with a quorum of 1. The results should take about 10-15 hours on an average computer.
Thanks,
-Uplinger
More here: https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=435Last year, we updated you on the progress our team has made in filtering the computational results from our time on World Community Grid and identifying promising candidate compounds to test in the lab. Since then, we have completed the filtering process and identified over 100 compounds that the simulations predicted should bind effectively to the target PDB:3MJY protein in the Leishmaniasis parasite. However, the only way to be certain is to move those compounds into in vitro testing. Due to limited funding, we focused on the 10 compounds with the highest predicted rating, and found that 4 of them do in fact show positive results in in vitro tests, with one showing an exceptionally promising result. This means that in vitro the compounds kill the parasites efficiently while not affecting human cells.
More here: https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=427Thanks to World Community Grid volunteers who contributed to Say No to Schistosoma, we have selected compounds from the grid-based screening for further testing. We collaborated with various laboratories to perform further computer analysis of 24 compounds using several software tools. These tools help by providing information about numerous features of the compounds such as toxicology, absorption, interactions, pharmacokinetics, and more. Quantitative Structure-activity relationship (QSAR) models were used to further evaluate the results. For more about QSAR, see here and here.
From the analysis, three compounds were identified as the most promising substances. For the next steps, we are continuing with in-vitro testing of these compounds to determine whether they might be viable options for treating schistosomiasis.
More here: https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=439The World Community Grid phase of the Discovering Dengue Drugs – Together project completed its computations a while ago. We have spent the interim period analyzing the results, retesting some of the calculations, modifying the underlying assumptions for the calculations, and testing compounds in the laboratory using in vitro and in vivo systems. We have recently made an exciting discovery using insights from the Discovering Dengue Drugs – Together project and additional calculations on our web portal for advanced computer-based drug discovery, DrugDiscovery@TACC. A small molecule has demonstrated high affinity at binding to and disabling the targeted dengue virus protease. A full description of this work is available online (see: U. Viswanathan, S. M. Tomlinson, J. M. Fonner, S. A. Mock, and S. J. Watowich, "Identification of a Novel Inhibitor of Dengue Virus Protease through Use of a Virtual Screening Drug Discovery Web Portal," J. Chemical Info. Mod, 54, 2816-2825, 2014). Furthermore, this compound shows signs of being able to effectively disable related flaviviruses, such as the West Nile virus. Importantly, our newly discovered drug lead also demonstrates no negative side effects such as adverse toxicity, carcinogenicity or mutagenicity risks, making it a promising antiviral drug candidate for dengue and potentially other flavivirues. We are working with medicinal chemists to synthesize variants of this exciting candidate molecule with the goal of improving its activity for planned pre-clinical and clinical trials.
More here: https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=341 and here: https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=413After additional laboratory testing, we have discovered that the seven drug candidates are very effective at destroying neuroblastoma tumors in mice, even at very low dosages, with no immediately apparent side effects. These results have been published in the peer-reviewed journal Cancer Medicine, available online since January 2014.
More here: https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=396We’re excited to announce that our collaborators at Scripps Florida have now optimized their NMR experiments and have been able to characterize the binding of promising ligands with the prospective allosteric sites on the HIV protease. These sites represent new footholds in the search for therapies that defeat viral drug resistance. The NMR experiment allows us to detect the location of the interactions between the candidate inhibitors and the protein, but unlike X-ray crystallography experiments, these interactions are measured in solution, which better represents the biological environment.
The researchers for the project are in the process of preparing and sending the next set of work for the project, but no ETA is available at this time on when the next set of work will be available to volunteers.
Ha, because of DC, I have not yet had to turn the home heat on!Now that it is getting cool out again and we turned our heat on I can throw some spare cycles back into DC.
Now that it is getting cool out again and we turned our heat on I can throw some spare cycles back into DC. I've never tried WCG before so I'll give it a shot.
Since starting FAAH-P2 on the 6th, I've received the following badges:
-- Bronze
-- Silver
-- Gold
-- Ruby
-- Emerald
-- Sapphire
Total run time for FAAH-P2 is 2y:121d:23:04:04 as of the last update.
Just ticked over 75 years combined for WCG overall.
New drug development partners
In a previous update, one of the problems we mentioned is that many pharmaceutical companies are not interested in developing drugs for neuroblastoma, because the potential market is relatively small. That’s why we are especially excited to announce that recently, two organizations that support drug development in Japan - the National Institute of Biomedical Innovation (NIBIO) and the Innovation Network Corporation of Japan (INCJ) - have shown interest in our project of TrkB antagonists as candidate anti-cancer drugs. In addition, the Association Hubert Gouin: Enfance & Cancer, which supports researchers who develop new drugs against high-risk neuroblastoma, is also interested in our TrkB antagonists project. We hope to secure their support for our project in the near future.
I was hoping that we would be part of the X-mas Race this year. However, it does not seem that we got signed up.
"Soon" - We've already received the corrected batches from Harvard and are working on our end to prepare them to run in beta.
Seippel