In bios I changed the settings to pcie 2.0 just to see what happens I don't get any issues when I run Crossfire 2 Cards. as long as its Card 1 in Slot 16x and Card 2 in Slot 8x but if I try using Card 3 with either first or second card I get issues. Most things I read say they get problems with Cfx in general. I'm using 5 screens as well. 5 screens CFx no problem, trifire I get a freeze. so it seems the only time I get issues is when im using my third card. any other configuration results in 0 problems everything runs smooth for hours.