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As much or more as most games will not run the cpu at 95-100% utilization all the time and zoning or loading a new level give the cpu a break.
Now a game will stress the computer in a whole different way with a wider variety of cpu instructions, memory access etc. but probally over an hour not cause as much heat. And of course Orthos etc. does nothing to stress the graphics card/system.
So its really not something one can apples to apples compare. Run Orthos for 6 hours then try your game. The ultimate stability test for you as a user is to be able to do what you want to do with the machine for as long as you wish without the machine having an issue.