That is going to put the pump at the top and the radiator at the bottom of the loop, where would you put the reservoir?
Bingo. Not only will a 140mm radiator prevent mounting the optical drive (along with the 2.5" and 3.5" sandwiched to it) it will also prevent you from mounting the other standalone 2.5" drive under the MB.
So a 140mm radiator will require the removal of ALL drive trays in the case, AND it will also end up under the GPU, preventing a long card from being installed.
I have the case under my desk with the side panels off as I type this, I'm not guessing. If you want a single loop for both CPU and GPU I think the only feasible option is a thick 120mm radiator, and I'm no expert water cooler but I don't like the idea of the pump being at the top of the loop. It's too bad you can't get the Asetek CPU/GPU combo outside of buying a PNY card. You could easily keep an i7 and a GTX680 cool in this case with such a cooler (if you keep the OC reasonable for both GPU and CPU).
I had no plan to run a reservoir. Also not mounting the 2.5" drive in the standard place. There is room to put it right behind the optical drive.
Everything I plan on doing will require cutting and removing parts. I also have no plans on using the other drive trays. They were the first to come out and go right back into the box.