Not necessarily. I switched to "bios 2" on the card itself, and used MSI Afterburner to set my voltages. After I adjusted my core voltage I HAD to toggle the "constant voltage" tab in order for it to hold the adjustment however. I was able to hit 1.2ghz, but had to up the voltage to 1.268...not really worth it for everyday use, but it did allow my system to score over 10k in 3dmark11, haha. My daily clocks are 1100/1425 @ stock voltage which is more than plenty for pretty much every any game at 1080, and the hottest I've seen it is 68C after playing Planetside 2 for 2+ hours.Isn't voltage hard locked?
So yes, but what type of monitor at 2560x1600 are you trying to hook up?
How could I hook up an LCD TV like this in an another room 20 feet away in this setup? But without the triple monitors.