As for your question, you don't need to do a thing. Just enable PhysX support in the drivers and you'll be using your GeForce for physics. Haven't seen it done with cards other than NVIDIA's, but it should work, because PhysX was ported to CUDA, which doesn't require SLI or anything like that to work. Just plug your card in a PCI-e slot, install PhysX drivers, enable the option and you should be set.
Absolutely..Depending on your GPU your performance obviuosly will vary.I think the benefits will come obviously when games start really making use of it.Benchies are one thing,but gameplay is more important.In Warmonger,running PhysX on my GTX280 only,nets me around~15-20fps less that running it on my 9800GT SC.With that said,its not like the performance on my GTX280 is shabby when running PhysX on it.It does free up resources using the second card.Hopefully,Mirrors Edge really shows what can be done and the performance will be clearer.Again,time will tell.