As a SFF case user, I've noticed that most of the compatibility issues with cards are due to the Height of the non reference PCB designs or the width where some of the cooler designs add a billion fans or whatever. Even my NCase can fit like 12.5" length designs.Reference cards have always been 10.5" long. The 1080 is only a quarter inch longer. It's not really going to be an issue unless you try to stick one into a prebuilt PC or certain SFF cases. But even mini-ITX cases these days are being made to accommodate larger video cards with unconventional designs.