I just got a 460 today and am in the process of playing some 'musical GPUs'. The 460 has replaced a 260 which is going into rig#2, the 450 will go over to either the server or rig#3 and the 9800GT I was planning on adding to my rig as a PhysX card. Question of the day is can I run both the GPU2 and GPU3 clients at once if I put the -gpu0 and -gpu1 flags in their respective configs? If not maybe I'll just put the 450 in with the 460 and run both on GPU3 clients. I see in the forums that some folks are having grief trying multi-GPU setups, anyone got a success story? If so what are your settings? Moar ppd for the Horde!