I'm a lefty, so I rebind EVERYTHING for EVERY game. Used to it now, so it's no big thing. Often I have to use programs like AutoHotKey when developers get neglectful. 'Back in the day' I used a joystick and mouse, lol. I came to shooters from the space sim genre (X-wing to Dark Forces). I had to force myself to learn the keyboard and the Numpad is the only thing that remotely works for lefties.
The upside is I've got a AutoHotKey template I've shared with several other lefties for when games like Dead Space and Witcher come to PC locked for default right handers.
Arrow keys plus mouse 4 lyfe
Since I have terrible muscle memory I need space between keys or I'll hit the wrong ones. Wasd is too packed together for me, so the extra dead space is good
I think you didn't give ESDF enough time to adjust to.