Works great with Overwatch. I couldn't believe the game actually shows "GTX 980 SLI" as my video card. Impressive.
But it will also run really well on a GTX 750 TI @ 1080p on high, you might not even be able to tell if SLI is working well.
Fallout 4's awful performance on my Radeon 280x Crossfire setup is one of the biggest reasons I decided to upgrade to a GTX 1070. There are also a few games that just never worked with Crossfire like Titanfall, I just gave up and disabled it. Multi-card setups are a pain, maybe it will get better with direct X 12, but I won't believe it until after it happens.