Depends on the OS you have installed, XP and Vista typically blow up and BSOD if you attempt to run them after swapping a motherboard. I haven't tried this with Win7 yet, but I have heard it is more tolerable to this than previous OSes.
In general, the chipset is key. If the motherboards you are switching between have the same chipset Windows (XP/Vista/7) will bitch a little, but it usually figures itself out. If the chipsets are similar, it may work, but if it is different chipsets thats when the explosions happen.
The Short of It: Win7 should be more resilient. Try it out, and tell us how it goes.
my original board is a GIGABYTE GA-EX58-UD3R and i would be going to a GA-X58A-UD3R...its the same x58 chipset. how do i go about restoring from my WHS? do i have to initially install windows
well im not sure why i didnt think of this...why do i even need to restore from WHS? im not formatting. i just swapped the mobo and it loaded just fine as if nothing happened. need to update a few drivers but so far it booted just fine