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I think if you set it to be the default sound device in the system prefs the keyboard volume control will work the way you want it to.
reviewer said:One important note:
When using this on OS X - you will NOT have software control of the volume. If you use the TRS audio outputs to connect to a set of studio monitors, you will want to get the Nano Patch or some other in-line audio attenuator.
There is a volume knob on the front of this device, but it is only for the headphone out.
For studio monitors? Probably looking at the aptly-named Mackie Big Knob or something of that nature.