Most card readers out today are already Vista-compatible because they use the USB bus (internal or external), which is designed (since Windows 98 SE) to be "plug and play." What you should be looking for is something that supports the latest technology... I've only found a few (though, off the top of my head, I forgot which ones) that support the newer SDHC memory cards (capable of storing 4GB or more memory).
EDIT: I was able to narrow down the list, somewhat, for multi-card readers that support SDHC. I don't have a multi-card reader myself, so I can't tell you which one(s) in particular to go for.
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