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Unless you have the new Websense Triton.... websense sucks.
We ran 6.3.3 for years and it was nothing but headaches. It had horrible eDirectory integration and its AD integration wasn't much better.
Websense web filter cannot block protocols or any ports other than 80 and 443.
I have demo'ed the following products and overall I feel like Cisco IronPort or m86 would fit your needs.
The cons of iron port though is that even their newest builds can't inspect ports other than 80 or 443. They also can't do protocol blocking (p2p, chat, skype, etc)
M86 can filter in realtime across all ports however it also can't do protocol blocking. They can however analyze HTTP and HTTPS GET requests across any non standard port so if you have a clever user trying to route web traffic over another port M86 will pick it up.
I really like M86's X strikes policy... but their AD integration could use some work. They also have a horrendous web interface that is based on Java and it crashes quite often. I am the only person inside of the interface though so it's only a problem to the people that administer it. On the user facing side it's pretty unobtrusive.