Spider-Man 3 will ship on multiple systems including Xbox 360, PlayStation 3, PlayStation 2, the Wii, PC, and Nintendo DS, the day before the movie debuts, but only the Xbox 360 and PS3 versions are similar in content. Incidentally, the PS3 version offers an extra little goodie -- the ability to play through the whole game as the new Goblin, while the Xbox 360 version offers Achievements and Xbox Live friends' lists but not online play.
Source (The X360 hands-on)
PS3 hands-on
I don't care about Achievement points and I'd rather play through the game as the Goblin (more game content FTW )
Other than that... game looks like a web-full of fun