Intel is has 65nm cores on the market now and AMD will be following suit soon. Both companies have or nearly have the capability to begin taping out 45nm cores and Intel hopes to have 32nm in production by 2009. IBM mentioned a month or two ago that they have begun working on lithography in the <20nm range. How long until we reach picometer lithography? Would engineering on such a small scale be possible with current SI-based substrates?