Haven't tested it yet. But new 5.0 Mako out with an option for its own frame gen model. Meaning lossless frame gen is not required. Though you can use LSFG.
https://github.com/eugeniosegala/MAKO/releases/tag/plugin-v5.0.0
Pick a Frame Generation model: Choose MAKO FG, LSFG Quality or LSFG Performance per profile and power mode. Switching between MAKO FG and LSFG needs a restart; LSFG Quality and Performance switch live. LSFG and LS1 still require your own Lossless Scaling installation.
https://github.com/eugeniosegala/MAKO/releases/tag/plugin-v5.0.0
Pick a Frame Generation model: Choose MAKO FG, LSFG Quality or LSFG Performance per profile and power mode. Switching between MAKO FG and LSFG needs a restart; LSFG Quality and Performance switch live. LSFG and LS1 still require your own Lossless Scaling installation.