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Is this is a Data ISO (like an image of a game disc or similar) then NoForgiveness' idea is probably the best router.
If it's a video ISO, then you'll need to use some sort of authoring software that can split the video and recreate the file system so that they'll play properly.
is an os. noforgiveness?
ah crap. googled NoForgiveness
how about burn it on a double layer DVD?