It can be incorporated into wordpress, but takes a bit of manual work. I did it for a while but then I got hacked off with wordpress and went for zenpages
This may not be what you are looking for, but maybe just making your own gallery with css or tables depending on what you are familiar with and then using lightbox. Just a thought.
There's a plugin for Gallery2 that integrates it with Wordpress... it includes the capability to synchronize the Wordpress user table with Gallery2 also, in case you want to offer private albums and such, so your users don't have 2 separate logins.