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Same problem here except it's buttons G7 and G4. I'm on an iMac with Windows 7 booted through bootcamp. When the mouse gets like this the problem persists whether I'm booted in OS X or Windows. Usually problem goes away on its own after a time or when I go into Setpoint and reapply the settings.
I added a few extra profiles with the same configuration to see if changing profiles would correct the problem. Haven't had the opportunity to see if that works.