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Using GTX 400 Series GPU & GTX 200 Series GPU In One System:
When combining a GTX 400 Series GPU with GTX 200 Series GPU, the GTX 400 Series GPU will fold FahCore_15 WUs while the GTX 200 Series GPU will fold FahCore_11 WUs. However, if the GTX 200 Series GPU attempts to fold a FahCore_15 WU, it will result in an error. To have a high probability of the GTX 200 Series GPU gets FahCore_11 WUs, use -advmethods flag (this may change in the future).
If you are still facing problems with the setup, then use these arguments with the correct GPU:
GTX 400 Series GPU (Fermi): -forcegpu nvidia_fermi
GTX 200 Series GPU (Non-Fermi): -forcegpu nvidia_g80
If it still doesn't work, you may want to run one instance of GPU2 Client for the Non-Fermi one and one instance of the GPU3 BETA Client for the Fermi one. IMO, you may want to use the Console Version of both Clients as all the files are included in it and it is a no-nonsense version which makes it easier to set-up.