I have been continuously having FILE_IO_ERRORs with SMP Client which will basically mean I would constantly have to reset the client after every work unit was done. I tried various overclock settings and stock. Basically, I figured out it was NOD32 AMON (realtime file system protection) that was causing it.
So incase anyone else is encountering this, check to see if your virus active scanner is enabled.
So incase anyone else is encountering this, check to see if your virus active scanner is enabled.