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Possible issues are that if you dont disable the other screens before gaming and they are extended (not cloned), you might lose a bit of vram.
And if say a video (or anything else, ie animated gif) be it in a media player or web browser is running on one of the screens, this can use cpu, memory, gpu and vram resources.
If the latter isnt a problem, you probably wont notice the slight lack of vram.
I have never completely disabled my secondary screens even though I only ever use 1 or 2 at a time.
Its much easier to just leave all 3 cloned cos then all I have to do is turn the screen on/enable the AV system and it is working.
But this is slightly different from having extended desktops.
ymmv
When I had an AMD card, it used to use 40W more just by enabling a cloned desktop, even when the 2nd screen was switched off.
Now I am on NVidia, it never uses more than idle power when running cloned.
I have read that running 3 screens at once takes NVidia cards out of idle but havent confirmed this.
ps for the curious, my 3 screens are:
PC monitor
Projector
AV sound processor (needs video sent to it to get 5.1 audio to it via HDMI)
If you ever do run into issues, you can set NVCPL to "Single Display Performance Mode" which from what I remember restricts hardware acceleration of 3D applications to the primary monitor only in an extended display setup. This can cause a lot of stuff to outright fail to run on secondary displays though, so its not really recommended. The default "Multiple Display Performance Mode" allows full 3D acceleration on all displays, and is what normally should be used.
Generally speaking though, running multiple displays usually will have an impact of some kind if you play games in Windowed or Borderless Windowed, rather than Fullscreen Exclusive mode.
At one time I had my monitors running at 144hz and 60hz at the same time now I can't get that option back. I tried everything so I switch monitors to using
(Windows Key and P) shortcut to switch to whatever display I want to use. Multiple monitors just get too much light exposure I tired 3 didn't like it so I'm down to two and usually don't have both of them on at the same time.