I remember seeing something like what you're looking for awhile back, maybe a year or so, reviewed on thetechzone.com or at least linked off of there. I can't remember what connection it used (USB2.0 or firewire), maybe it was both, but I do remember it got a good review, only thing it might need is a fan to cool the drives off. I'll see if I can find it or google it.
edit: Well I can't for the life of me find that article again. But from what I did find in my searching was that it might just be as cheap to look for multiple single USB2.0 enclosures (which can be found in abundance it appears ) and stack them or something.
Yes it's for a Shuttle system.
I was thinking of getting 3 or 4 single ones but I was trying to reduce the amount of wires (power and interface) on my desktop.
Plus I would need to get a usb2.0 hub. I was thinking it would look so much nicer to have one enclosure about the same size as my Shuttle housing all my extra stuff (storage HDs, DVD buner)