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DDR 1600 (O.C.)

You can double check this in your motherboard settings, but it probably means there no divider high enough to use a 266Mhz FSB processor with 1600Mhz memory (ie, no 3/2 divider). In other words, depending on which processor you have, you may need to overclock the processor in order to run your memory at 1600Mhz.

Those sticks should work - they may just run at a lower speed. Which shouldn't actually slow down your computer, because if I recall correctly the core2s perform best at a 1:1 FSB ratio.
 
I recently purchased an MSI Motherboard and it says it supports "DDR3-1600 (O.C.), DDR3-1333, DDR3-1066, DDR3-800". I'm unsure what the "(O.C.)" means. Will it natively support DDR3-1600?

OC means overclock or overclocked. So, no it won't "natively" support 1600. You'll have to OC the memory controller to run the memory at 1600.
 
Intels official specs for x58 call for 1333MHz, anything over that is technically an overclocked set of RAM
 
Thanks for the response. Even though the 1600 speed isn't native, all ddr3 1600 will be supported but will run at a lower speed, correct? Will there ever be a complication from doing so?
 
Thanks for the response. Even though the 1600 speed isn't native, all ddr3 1600 will be supported but will run at a lower speed, correct? Will there ever be a complication from doing so?

Supported by the motherboard, yes. Although, some ram doesn't work with particular motherboards for one reason or another (default/stable voltage is higher than what the motherboard is willing to give, etc).

Running slower than spec is perfectly fine as you can tighten the timings a bit or lower the required voltage (or both! if you are feeling adventurous).
 
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