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Possible, yes. Easy? No. Cost efficient? No.
I mean, technically you could use clear glass, but that would be pretty hard to make and brittle as well. Clear acrylics might work, but plastics tend to have static issues that's not good for a lot of parts. I'm sure there is some fancy transparent material out there that is suitable, but it's likely much more expensive.
Also, on more complex or multilayer boards or those that require ground planes, you wouldn't be able to see through them anyway because of the copper / traces.