Can I run a R9 290 with my Fortress-650?

That should be fine, looking at your PSU's specs - even with a high watt cpu you should have a lot of breathing room. Now if you're going crossfire, that's another story...
 
you should be fine with a single card.

You might not be able to reach a max overclock on the cpu and gpu, depending on what is being used, but you will be able to run at stock no problems.
 
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