it could be a power supply issue... i mean a hard drive does take about 25 watts of you psu away.. he could be on the edge of all his watts and freeing a hard drive feeds the card more... thats my guess
Much better, Running four sticks of ram is something that can really fuck up your clock speeds. Go into your bios and lower the timings, slowly. Also make sure you have the latest drivers for your videocard.
Most of the time gamers/enthusiasts do not fill up more than 2 memory slots. Adding a third and then a fourth actually downgrades the CPU performance by going down to 333MHz FSB or even lower.
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