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I am pretty sure you can't mix cards like that and make them get along. Has to be the same family 6xxx. Its not the driver - it was certified by blizzard to work on all cards 3000 and up. TDRs can be caused be heat, which
could be a cause since you're running 2 cards in your system. Honestly i'd just remove the 5xxx card....
Diablo 3 runs fine on my 7970cf box with catalyst 12.4, i'm level 17 so far.
i think i have pinpointed the problem.. if you have two cards that arent in the same family you cant even have amd overdrive enabled to control fan speed.. which is what i was doing.. since i have disable overdrive completely and turned off manual fan control i havent had a problem... ill keep testing and update with results..