Raid 640G & 500G?

Sure its possible. Keep in mind it will only utilize 500 GB of that 640GB drive. How well it will work will depend on how good the RAID controller is.

Oh and BTW - I wouldn't recommend this unless you are just testing at home. I dont think I would trust this as a backup solution. Might be OK for a RAID 0 if you are just looking for some extra throughput and don't need the redundancy.
 
And the size would be limited to the smaller drive too.

It will work. If you already own the drives go for it.

Don
 
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