Any suggestions on a good offsite backup program?

[burritoincognito]

I'm looking for something we can use for multiple clients.

We were using FastPC, but we had to constantly babysit failed backups.
We've tried using Intronis, but their compression leaves a lot to be desired. What was a 90GB backup for FastPC was a 140GB backup on Intronis.


Needs to support standard file backup, as well as Exchange, and SQL databases.