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Good news: I just started bigadv on my SR-2 and the first WU is a 2685. I'm seeing seeing 69K PPD while also GPU folding. For reference, running standard SMP I was seeing about 35K with GPU folding (four clients) and 50K with idle GPUs. I'm running two standard clocked X5650s.

Again this is just guesswork without actually owning one, but I wouldn't run more than two GPU clients on a SR-2. The more GPUs employed, the more CPU cycles are consumed with some WUs like the 353-pointers being very bad in that respect. This affects -bigadv bonuses drastically. Even then, with an SR-2 system I'd probably only run Fermi GPU architecture because the production yields better PPD vs processor cycles consumed.Yes, because of the bonus structure, you have to balance the PPD hit against the overall greater PPD of adding GPUs. My goal was maximum PPD over the weekend before I had to RMA the board. I'm still planning to test more configs as soon as I get the SR-2 back from EVGA (another week or two).
Not a [H] Folder, but I'll post this just to illustrate what's possible with dual hex cores on an SR-2.
Folding machine in sig munching on a 2685...
141,000 PPD @ 590W = 238.98 PpDpW
Yep, I thought I saw something to that effect. So yeah, hex-cores and SR-2 is a great -bigadv combo...From another thread:
141,000 PPD @ 590W = 238.98 PpDpW
His is at a little over 4GHZ with X5650s.