Yep. I have 2 x2.5 drive, a h100i and a 670 in mine with the sfx-L 500w powersupply. Its a little bit tight where the GFX meets the powersupply but you can squeeze it. IF you went with the standard SFX size more room opens up.
Anybody have some build pictures with a V3 of this case and an SFX-L pus? I have my case ordered but just trying to finalize my PSU purchase. Hoping to see how much clearance there is with an SFX-L psu.