Yes there are multiple factors - which is why you must:
- Monitor (Per pin 12VHPWR monitoring via Astral or WP2 or PSU)
- Prevent (WP2 or PSU)
- Connect firmly
- Don't bend
- Don't connect more than 50 times (lol)
- Have spare cables
The 12VHPWR cables are basically the problem with the whole thing. Seasonic themselves only warrants the cables for 50 re-connections. That is a good amount - but compare to your Molex that's like nothing, at least for me who changes cards A LOT.
Source...
I'm partial to getting your OEM PSU cable. If you have an MC nearby they stock Corsair ones - if not you can get them pretty quick off of Amazon and I think Corsair direct.
I think basically they have pegged the cable as the problem in almost all of these cases. So just have a couple on hand. For around $20 each - worth it.
AI1300TS in HWiNFO alongside the Astral 5080 per-pin. PSU will first scale back power (75%) - then shutdown GPU - https://www.msi.com/blog/introducing-gpu-safeguard-advanced-gpu-protection-on-msi-next-gen-power-supplies. I love not having to have another app. Can be tuned with MSI Afterburner...
My math was:
$200 more money for the right, native ATX 3.1 solution (my PSUs are Seasonic Prime Platinum 1300W, Corsair AX1000, AX1600i)
Better protection
In a world of GPUs with rising values every day, I enjoy the full peace of mind.