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Mantle, like DirectX 12 has an abstraction layer and as such it can work on any highly programmable graphics architecture. The only thing NVidia needs is the Mantle SDK and they could write a driver for it.
Also, keep in mind that designing Mantle for GCN only would mean major work whenever...
The problem with Blizzard is that they have sold out back in 1994, and getting to become independent is impossible for them cause they don't have enough money to do so (would cost them billions I assume).
Hearthstone isn't even in open beta yet and it's already quite popular.
HoTS isn't actually a DOTA clone like DOTA 2 and LoL are. They are doing something different with it.
The graphics are not cartoony. Look up the definition of the word cartoon.
But yes, the graphics are not realistic, but that doesn't mean it's for kids. And saying that both visual styles are the same because they are both "cartoony" is the same as saying that Intel CPU's, AMD CPU's, NVIDIA...
The visual design of Diablo 3 is totally different than the one in WoW.
And what makes it feel like a kids title? I mean, from some perspectives I could say the same about Diablo 1 and 2.