I have a 10980XE on an ASUS ROG Strix X-299-E Gaming II mobo and a watercooled EVGA 2080 GPU. I have the CPU cooled by a Corsair 110i cooler and cooling is not an issue. I can't even get the CPU to throttle with any of the AIDA64 stress test or even PRIME. I have the system set to use ASUS own...
I have done exactly that, moving to a 2 TB NVME drive (Intel 660P) from a 1 TB SSD. I also installed a i9 10940X whis is OK but not a great overclocker.
The ASUS TUF X299 Mark 2 had a new bios released last weekend (2002) which "Add support for Intel® Core™ X-Series 10000 Processor Family" . It also does not kill the Kaby Lake-X 7740X processer either. I have both with the new bios. Everything is just fine...