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Technically, OEM means it is tied to one computer. So, if, in a year, you scrap your current PC, you should buy a new copoy of Vista for it. Retail, would let you move the license to a new computer as often as you'd like. Some people will tell you that they've been able to upgrade their PC components a few times and still call in the OEM activation. Others will say they couldn't, and still others will come in screaming that it violates the EULA. Whether you want to follow the EULA to the exact letter, and/or take your chances with OEM, that's up to you.
As for official support, retail means you can go to Microsoft for any issues. OEM licenses have their support handled by the OEM, like Dell, HP, etc. Honestly though, who calls Microsoft and pays for support? This difference is really a non-issue, especially for the reads of this board.