Please drop your [H]ard card at the door...There is zero reason to not have at least a 128~512GB SSD in the latter half of 2018 if you are a member of this site. You cannot begin to argue a use case that prohibits you from using a small, super fast SSD for OS/critical applications and a larger spinning drive for bulk storage. Hell modern platforms like the Ryzen AM4 offerings have their wonderful caching options that would make a 2TB HDD feel super fast with a small 128GB SSD in cache mode.
I can.
1st, your machine generally doesn't get turned off, boot times are immaterial, the OS is ESXi
2nd, All your user systems are VMs and your datastore is a separate larger SSD