Same here. I can check my e-mail using any computer with full Internet access using any browser. I could even check from a phone if I had cell Internet access (too expensive!) No virus can infect my e-mail client because there is no e-mail client (a big problem for Outlook users in particular really.) I suppose if IE were used it might be possible for an e-mail to infect it, but the simple solution is to use Opera or Firefox anyway. (Not that I think I'll ever even see such an e-mail. Gmail's spam filters are pretty incredibly accurate in my experience.) Any client, any location. What's more, it has such a clean and efficient interface. I could do without all the messy AJAX code in the back, but given that it even works in Opera without any problems these days and still manages to load very quickly I can live with it. (The irony is, the AJAX actually makes it run better at times since it doesn't have to do as much actively as a standard web interface. That's why I keep it on the enhanced mode or whatever they call it really.) Overall it's just a 10x cleaner and more efficient way of handling e-mail in my experience. I love how everything can be kept fully online where I can access my e-mail from any system and keep nothing locally. (I just have to be sure to log out if I use another system obviously. Clearing the cache probably doesn't hurt either, but with the way gmail works I'm not sure how necessary that really is.)gmail FTW
That said, I use mostly gmail accounts so it makes setup easy. I don't think you can use Thunderbird with hotmail/live accounts without paying a fee and I have no desire to pay a fee for that.
I use Lotus Notes 8.0 at my job because I have no choice. I use Outlook 2007 for my personal and [H]ardOCP E-Mail. Why? Because I know Out look very well and on my network I need Exchange integration. (Exchange 2009 server is going online soon here.)
"I have to because my job uses it" aside, why does anyone use a separate client to check their email? What are the benefits to using (for example) Thunderbird to check your email (which, for example, is gmail) rather than just opening a tab in your browser and using gmail itself?