Homefront, WK40K: Dawn of War II - Retribution and Battlefield 3 cause the biggest pings on my radar right now. After them...Max Payne 3, perhaps Sword of the Stars II and Age of Empires Online. And probably Portal 2 at some point, though not immediately.
other then that, I really try and not pay attention to future titles. I think over-hyping myself up for them just gets me in trouble when they finally come out. I'd rather be surprised and wait for game to stand the test of time a bit. This also saves me time in the long run, and makes the game experience much more immersible as I don't have all these memories of screenshots and videos and opinions in the back of my head...
Just pre-order through Amazon:
Brink
Deus Ex Human Revolution Augmented Edition
Diablo III
Battlefield 3
Also looking forward to:
Major League Baseball 2K11
Shogun 2: Total War Limited Edition
Portal 2
F.E.A.R 3
Alice: Madness Returns
Batman: Arkham City
Aliens: Colonial Marines
Mass Effect 3
Tomb Raider
Will buy on release day:
Gray Matter
Deus Ex: HR
Rage
DNF
Mass Effect 3
Guild Wars 2
BF3
Hold out on:
The witcher 2(when I'm finished with the 1st Witcher)
Crysis 2
Dragon Age 2
SW: TotoR
Elder scrolls V (after i beat ME3; because i wont really be playing anything else once i get it)
I have hope for:
Microsoft Flight
A new mechwarrior! (or at least some info, anything.....)