what is the difference between these 2 Win 7 x64 Digital River ISO?

Couldn't tell you since the link goes directly to the download. What does the documentation/notes say? anything more than the bit and language? Dates?
 
x17-58997.iso is the Media Refresh SP1-U:

This new issue fixes a minor issue when using the original Windows 7 SP1 media to install Win7 w/SP1 on a new PC. The Windows 7 SP1-U (Media Refresh version) adds the installation hotfix KB2534111, and nothing else. No other changes have been made to the Windows 7 with SP1 ISO image despite there are several updates that have been released after the original Windows 7 SP1 was released.
 
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