Suggestion.
Rotate the GFX Card so MB and Card face the same way, that way you can have a clear side panel for people into that.
Also wish such a design was more common without making the case larger. But as Silverstone hasn't managed it then I'm not excepting a smaller company/individual to lead the way.
Lian Li's O-series cases are laid out that way, though they are much larger than the LRPC. Aside from wanting a window, there is no reason to do it, and plenty of reasons not to. For example, if we just flip the GPU, there's a couple of things that become apparent:
Right away we can see the PCIe slot will potentially be blocked by the GPU, and we'll need a much longer shielded flexible riser (which adds cost and potentially affects performance/reliability). We can move it up vertically or over horizontally to give the connector some room, but there's another problem:
Having the GPU exhaust directly into the CPU area is the last thing you want if your goals include the words "cool" and "quiet." The current unflipped layout makes a lot more sense for both the riser connection and airflow:
Now, it's true that open-cooler GPUs exhaust from both sides, but the way video cards are designed (and the offset of the rear bracket in particular) means if you want to isolate the GPU like I've done with the LRPC, there's actually some room for air to flow:
Some GPUs are also designed for this side to be the primary or secondary (in blower cards) exhaust, so blocking it off is a poor idea.
Aside from those problems, there's the issue of how would the GPU, CPU, and PSU get air with a window? Do we punch the window full of holes? Dust filters are obviously out, as well.
So it would be bigger, perform worse, and accumulate dust. Ultimately, flipping the GPU just to add a window involves too many sacrifices, and makes little sense for the design goals of the LRPC.