Realistically speaking, is this a game that can be played 1 or 2 hours (tops) a night and still be enjoyed? I have kids, job, wife, friends... etc.
So far It seems that you could. Skills can run while you're not logged in and you can complete missions in a half-hour or so, with some missions taking only 15 minutes (I haven't run a mission that's taken more than an hour to do).
The only issue I could see you running into is when you have to travel great distances; you can spend 2 hours traveling, but with autopilot you can leave and go cook dinner or something. (just make sure you're not going through low-sec space when you do leave the PC)