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Barracuda all the way. I have yet to find anything that works better on a consistent basis and I have test almost all of the major products.
You using Exchange 2K3? The built in IMF does a decent job. For our clients on budgets..we're also having good luck combining the IMF...with using Endian as their firewall, as Endian does transparent proxy scanning of traffic for viruses, worms..as well as SPAM. And recently introduced malware (ad/spy) in their latest release.
Combine IMF with Endian..and you have a fairly effective zero cost solution. If you have a firewall that you cannot replace with Endian....we've had Endian just work as an SMTP gateway behind the clients primary firewall.
Since you're using NOD32...keep your eye out for their filter for Exchange Server...coming in a bit. Their current version already does a great job with phishing mail in the XMON.
Combine IMF with Endian..and you have a fairly effective zero cost solution.