Thanks for all of the help, I'll be going with Vista 64 on this build. I have a Creative XFI extememusic in my current system, but I think that i'll just be using the on board sound of the new board and skip the whole soundcard thing this time around.
Good choice. I have 64bit and no real issues beyond Creative. The few others they either had a 64 bit driver and in one instance my Reg Cleaner and Anti Spam programs did not work and they did not have a 64bit version.
Oh ya, also Adobe Flash is not 64 bit compatible....not sure if this is a Vista issue or 64bit in general.