I have a 5870 and an 8500 in my W7-64 system and am using the latter primarily for running a 3rd monitor. I do distributed computing using the BOINC platform and getting drivers installed and configured so that the 5870 was detected and able to do work was a PITA although I eventually succeeded for the most part. The one outstanding issue that I have is that aero isn't working and all windows will say is that one of my drivers isn't WDDM compatible, but not which one is the problem. I'm running the 10.9 and 258.96 drivers on my cards at present.