Optimizing Threadripper is entirely about cooling. I have a 3990x in a 4u enclosure and I use an Enermax AIO with 3x Noctua industrial fans. Yeah, it's loud, but it's cold. I can sustain all core boosts of 4.1ghz with PBO enabled under 100% CPU usage. Enabling PBO increased performance exactly 25% on cinebench.
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