I've been using JungleDisk with Amazon S3, overall I've been pretty happy with it, it's fairly cheap. JungleDisk now offers the rackspace storage cloud as well. I'm staying on Amazon S3 as many of our linux machines run s3cmd and backup to the same amazon s3 account. We also use Mozy Pro, it costs more but it allows for centralized management and you can specify what you want users to have backed up.
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